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S by enzymes, e.g., enamelysin (matrix metalloproteinase 20, Mmp-20) and kallikrein 4 [49]. The ways in which these proteins guide the formation of HA in enamel is unknown. There are, however, some important clues from recent studies. In the teeth of mice that produce a truncated form of ameloblastin, enamel fails to appear [50,51]. These mice also have reduced expression of amelogenin with no app
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Larreal-RamirezPagecations and anions [62]; the formation of such chains could also be true of the calcium phosphate prenucleation clusters. 2.2 Pathologic Calcification: Role of IDPs Calcifications occurring in unwanted places ?the aorta, salivary glands and soft tissues, are all associated with IDPs. To illustrate, salivary stones occur when mucins, such as statherin, an un-folded protein [63],
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Rly regulated, overexuberant response to infection so that levels of expression after infection often exceed those seen in WT mice. It is also of interest to note that several of the proteins (13 proteins out of 59) that were present in increased amounts in the uninfected SP-A-/- mice respond to infection by reducing their levelsAli et al. Proteome Science 2010, 8:34 http://www.proteomesci.com/con
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Mutant cells and therefore lowering the cancer escape mechanisms and also decreasing toxicities from paradoxical MAPK activation [28], such as the development of cutaneous squamous cell carcinomas [29]. The majority of uveal melanomas bear a mutually exclusive activating mutation in either GNAQ or GNA11, resulting in overlapping functions in melanoma cells with the constitutive upregulation of the
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An N-terminus with small acidic motif (DSpSpEE) that is also found in SIBLING proteins [65]. When solubilized, statherin has a random coil conformation. When bound to HA, it takes on a more alpha-helical structure exposing a bacterial binding site [63], leading to bacterial entrapment. Another example is the role of the IDP, DMP1, in preventing kidney and cardiovascular calcification. The double k
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Unteers' lung found significant decreases in levels of SP-A [28]. Unfortunately, there was little overlap in the sets of identified proteins between our studies and therefore little basis for comparison. When the DEF and RED proteins are individually examined as subgroups of the identified proteins, the changes are similar to those noted for all proteins. In both of these groups of proteins, more
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If somebody desired to relieve themselves sexually in the past, they might have had a publication or a paper to look through. This probably would have suggested that a minimum of one person would have seen them purchase it.There is the chance that this was not something that troubled them, or it might not have actually fazed them. And when they were no longer interested in a magazine/paper, they w