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EN activates the Akt/ mTOR pathway. Several studies have demonstrated the activation of the Akt/mTOR pathway in various sarcomas [7?]. To our knowledge, there is no report of an analysis of the roles of HSP90 and the Akt/ mTOR pathway in UPS. Another signaling pathway that involves HSP90 is the mitogen-activated protein kinase (MAPK) pathway, which plays a key role in the transduction of extracell
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E data: CGT. Wrote the manuscript: RHuang, XL, RHolm, JMN, CGT, ZS. All authors read and approved the final manuscript. All authors read and approved the final manuscript. Acknowledgments This study was financially supported by grants from Inger and John Fredriksen Foundation and Radium Hospital Research Foundation and The Norwegian Cancer Society. We thank Ellen Hellesylt, Mette Synn e F sund, Ma
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Icine, Faculty of Medicine, University of Oslo, Oslo, Norway. 3Departments of Gynaecology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway. 4Departments of Gynaecology, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway. Received: 27 January 2015 Accepted: 25 JuneReferences 1. Eskander RN, Tewari KS. Incorporation of anti-angiogenesis therap
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